Patterns of HIV drug resistance and molecular epidemiology of HIV in Georgia


Project title: „Patterns of HIV drug resistance and molecular epidemiology of HIV in Georgia”, BTEP/ISTC, G-2103; Project Duration: 01.02.2014 - 31.07.2015
Project Summary
a). The goal:
• Analyze patterns of HIV drug resistance
• Evaluate time trends in molecular epidemiology of HIV
• Establish national HIV sequence database
b) Implementation:
• Estimate the prevalence of transmitted drug resistance (TDR) among newly diagnosed HIV patients
• Characterize drug resistance profile among ART-experienced patients 
• Characterize distribution of HIV subtypes among newly diagnosed HIV patients enrolled in the study
• Evaluate time trends in subtype distribution

The proposed study is implemented by the National Center for Diseases Control and Public Health (NCDC) in collaboration with the Infectious Diseases, AIDS and Clinical Immunology Research Center (National AIDS Center). As the leading institution NCDC takes overall responsibility for project management. All proposed laboratory methods is performed at the laboratory of molecular medicine of the National AIDS Center. Laboratory group includes scientists from NCDC and National AIDS Center. National AIDS Center is responsible for selection and recruitment of study subjects.
C). Expected results:
Within the proposed study will be expand knowledge on HIV drug resistance and better understand driving forces of the epidemic in Georgia. The long-term objective is to move obtained knowledge into effective treatment and prevention strategies. Research results will be sent to the doctor's and will be used for better treatment /care. The study is anticipated to generate valuable knowledge to guide design of effective prevention and treatment interventions.